of some physical and chemical properties of drug and excipients through the is required in the
development of dosage forms.
Preformulation is defined as a critical step in research and development process where the
physicochemical properties of drug and
excipients used are characterized in order to formulate stable and effective
API characterization and identification
(API) was procured from Hetero labs Hyderabad. as gift sample. Identification
of drug was carried out by various pharmacopoeial guidelines.
and odour of API were characterized and recorded using terminology.
of piroxicam in different solvents was studied. The solubility of piroxicam was
tested in various solvents.
point of piroxicam was determined using melting point apparatus. Test was
carried out by taking a small amount of API
in a capillary tube with one end closed and placed in melting point apparatus.
The melting point was tested in triplicate.
Loss on drying
3gms of piroxicam was taken in glass plate and
kept in an hot air oven. Temperature was set at
and the powder was weighed to constant weight. Distribute the sample evenly as practicable by
gentle shaking to a depth not crossing 10 mm. Place the LOD bottle in the oven at 105°c by for 4 hours. After drying is
completed, open the oven, close the crucible and allow it to cool at room temperature in
desiccator for 30 minutes. Weigh the crucible and calculate the percentage LOD.
of empty crucible = W1
of crucible + sample = W2
of sample = W2-W1
of crucible + sample after drying = W3
in Weight of sample after drying = W2-W3
(% w/w) = (W2 – W3) /(W2 – W1)x 100