5.1 1050C and the powder was weighed to

5.1
Preformulation studies

Determination
of some physical and chemical properties of drug  and excipients through the is required in the
development of  dosage forms.
Preformulation is defined as a critical step  in research and development process where the
physicochemical properties of drug  and
excipients used are characterized in order to formulate stable and effective
dosage forms.

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5.1.1
API characterization and identification

Piroxicam
(API) was procured from Hetero labs Hyderabad. as gift sample. Identification
of drug was carried out by various pharmacopoeial guidelines.

I.
Organoleptic properties

Colour
and odour of API were characterized and recorded using terminology.

II.
Solubility

Solubility
of piroxicam in different solvents was studied. The solubility of piroxicam was
tested in various solvents.

IV.
Melting point

Melting
point of piroxicam was determined using melting point apparatus. Test was
carried out  by taking a small amount of API
in a capillary tube with one end closed and placed in melting point apparatus.
The melting point was tested in triplicate.

V.
Loss on drying

 3gms of piroxicam was taken in glass plate and
kept in an hot air oven. Temperature was set at

1050C
and the powder was weighed to constant weight.  Distribute the sample evenly as practicable by
gentle shaking to a depth not crossing 10 mm. Place the LOD bottle in the  oven at 105°c by for 4 hours. After drying is
completed, open the  oven,  close the crucible  and allow it to cool at room temperature in
desiccator for 30 minutes. Weigh the crucible and calculate the percentage LOD.

Calculation

Weight
of empty crucible                               =          W1

Weight
of crucible + sample                           =          W2

Weight
of sample                                            =          W2-W1

Weight
of crucible + sample after drying       =          W3

Loss
in Weight of sample after drying           =          W2-W3

LOD
(% w/w)                                                 =          (W2 – W3) /(W2 – W1)x 100

x

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