Platelet apheresis is a method of collecting platelets performed by adevice which separate platelets and return the rest of blood to the donor in asafely manner. Although platelet aphaeresis procedures are well tolerated than wholeblood donations significant level of adverse events (AEs) occur during andafter the procedure. Those AEs can be much severe in apheresisprocedures with comparison to the whole blood donations. AEs to apheresis procedures can be categorized as local or systemic. Local reactions include hematomas, brusing and phlebitis as a result ofdefective venepuncture and irritation or allergy to needles. Citrate toxicity is known to be the most frequent systemic reaction inapheresis occurs as a result of the anticoagulant acid- citrate-dextrose.Chelation of calcium ions by citrate causes hypocalcaemia which can bepresented as per oral tingling and parasthesia, chills, nausea, twitching,tremors or severe symptoms like carpopedal spasms, seizures, tetany and cardiacarrhythmias.
Vaso vagal reaction can be triggered by the anxiety and tensionfor the undergoing procedure or due to the pain causes by the venepuncture. Itis characterized by the pallor, sweating, dizziness, nausea, hypotension andsyncope. Adverse effects due to platelet apheresis are mostly under reported.This is mainly due to the high tolerance of the regular platelet apheresisdonors. Being most frequent adverse effect of platelet apheresis citratetoxicity is highly under reported as the mild symptoms such as peri oraltingling and parasthesia are well tolerated and not complained by the donors. Thereforeaddressing and reporting of each and every adverse event lies a greaterimportance in ensuring the donor safety and stabilizing the donor pool.No study has yet been carried out in Sri Lanka in relevant to adverseeffects in platelet apheresis.
The scarcity of studies done elsewhere in theworld, demands for more research as to improve the donor safety and to promoteapheresis procedures. · To assess the frequency of adverse events due to platelet apheresisdonations· To evaluate donor variables as potentialrisk factors for different types adverse events (AEs) during apheresiscollections· To assess the knowledge and attitude onadverse effects of apheresis procedures in platelet apheresis donors· To identify the frequency ofunderreported adverse events as a result of the tolerance by the donors